Antje Knopf

About

I am - a curious scientist, dedicated to translate state-of-the-art research into practice - a passionate instructor, enjoying to guide, educate and empower emerging scientist - an accountable and efficient project manager, committed to motivate stakeholders for a joined vision - an eager networker, who loves to connect people facilitating scientific synergies

Work

University Bern

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Prof for applied data sciences and decision support systems

Switzerland

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sitem-insel AG

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adademic lead / director

Switzerland

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TU Dresden

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Affiliated Professor

Germany

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Hochschule für Life Sciences FHNW

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Professor

Switzerland

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Paul Scherrer Institute

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Guest Scientist

Switzerland

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University Hospital Cologne

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Scientific Project Manager

Germany

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Carl von Ossietzky Universität Oldenburg

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Guest Professor

Germany

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University Medical Center Groningen

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Associate Professor / IUS Promovendi

Netherlands

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Institute of Cancer Research

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PostDoc

United Kingdom of Great Britain and Northern Ireland

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University Medical Center Utrecht

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Visiting Research Fellow

Netherlands

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Paul Scherrer Institute

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PostDoc / Research Assistant

Switzerland

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ETH Zurich

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Research Assistant

Switzerland

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National Institute of Radiological Sciences

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Visiting Research Fellow

Japan

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Education

Cologne Business School

Germany
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EMBA

Heidelberg University

Germany
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PhD in Physics

Heidelberg University

Germany
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Diploma (M.Sc.) in Physics

Heidelberg University

Germany
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M.Sc. Medical Physics

Publications

A review of the clinical introduction of 4D particle therapy research concepts

Physics and Imaging in Radiation Oncology

journal-article

Toward Closing the Loop in Image-to-Image Conversion in Radiotherapy: A Quality Control Tool to Predict Synthetic Computed Tomography Hounsfield Unit Accuracy

Journal of Imaging

journal-article

Toward Closing the Loop in Image-to-Image Conversion in Radiotherapy: A Quality Control Tool to Predict Synthetic Computed Tomography Hounsfield Unit Accuracy

Journal of Imaging

journal-article

Possible association of dose rate and the development of late visual toxicity for patients with intracranial tumours treated with pencil beam scanned proton therapy

Radiation Oncology

journal-article

Imaging in Particle Therapy

edited-book

Technical note: development of a simulation framework, enabling the investigation of locally tuned single energy proton radiography

Biomedical Physics & Engineering Express

journal-article

A survey of practice patterns for real-time intrafractional motion-management in particle therapy

Physics and Imaging in Radiation Oncology

journal-article

A survey of practice patterns for adaptive particle therapy for interfractional changes

Physics and Imaging in Radiation Oncology

journal-article

Technical note: Flat panel proton radiography with a patient specific imaging field for accurate WEPL assessment

Medical Physics

journal-article

Anthropomorphic lung phantom based validation of in-room proton therapy 4D-CBCT image correction for dose calculation

Zeitschrift für Medizinische Physik

journal-article

Robustness assessment of clinical adaptive proton and photon radiotherapy for oesophageal cancer in the model-based approach

Radiotherapy and Oncology

journal-article

Deep learning based 4D‐synthetic CTs from sparse‐view CBCTs for dose calculations in adaptive proton therapy

Medical Physics

journal-article

Clinical necessity of multi-image based (4DMIB) optimization for targets affected by respiratory motion and treated with scanned particle therapy – A comprehensive review

Radiotherapy and Oncology

journal-article

Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future

Frontiers in Oncology

journal-article

Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future

Frontiers in Oncology

journal-article

Diaphragm-Based Position Verification to Improve Daily Target Dose Coverage in Proton and Photon Radiation Therapy Treatment of Distal Esophageal Cancer

International Journal of Radiation Oncology*Biology*Physics

journal-article

Technical Note: First report on an in vivo range probing quality control procedure for scanned proton beam therapy in head and neck cancer patients

Medical Physics

journal-article

Head and neck IMPT probabilistic dose accumulation: Feasibility of a 2 mm setup uncertainty setting

Radiotherapy and Oncology

journal-article

Clinical suitability of deep learning based synthetic CTs for adaptive proton therapy of lung cancer

Medical Physics

journal-article

Optimizing calibration settings for accurate water equivalent path length assessment using flat panel proton radiography

Physics in Medicine & Biology

journal-article

Executive Summary of Clinical and Technical Guidelines for Esophageal Cancer Proton Beam Therapy From the Particle Therapy Co-Operative Group Thoracic and Gastrointestinal Subcommittees

Frontiers in Oncology

journal-article

Executive Summary of Clinical and Technical Guidelines for Esophageal Cancer Proton Beam Therapy From the Particle Therapy Co-Operative Group Thoracic and Gastrointestinal Subcommittees

Frontiers in Oncology

journal-article

Assessment of a diaphragm override strategy for robustly optimized proton therapy planning for esophageal cancer patients

Medical Physics

journal-article

Range probing as a quality control tool for CBCT‐based synthetic CTs: In vivo application for head and neck cancer patients

Medical Physics

journal-article

Dosimetric influence of deformable image registration uncertainties on propagated structures for online daily adaptive proton therapy of lung cancer patients

Radiotherapy and Oncology

journal-article

An approach for estimating dosimetric uncertainties in deformable dose accumulation in pencil beam scanning proton therapy for lung cancer

Physics in Medicine & Biology

journal-article

A comprehensive motion analysis – consequences for high precision image-guided radiotherapy of esophageal cancer patients

Acta Oncologica

journal-article

Towards the clinical implementation of intensity-modulated proton therapy for thoracic indications with moderate motion: Robust optimised plan evaluation by means of patient and machine specific information

Radiotherapy and Oncology

journal-article

Roadmap: proton therapy physics and biology

Physics in Medicine & Biology

journal-article

Consensus Statement on Proton Therapy in Mesothelioma

Practical Radiation Oncology

journal-article

Deep learning prediction of proton and photon dose distributions for paediatric abdominal tumours

Radiotherapy and Oncology

journal-article

Clinical practice vs. state-of-the-art research and future visions: Report on the 4D treatment planning workshop for particle therapy – Edition 2018 and 2019

Physica Medica

journal-article

Comparison of the suitability of CBCT- and MR-based synthetic CTs for daily adaptive proton therapy in head and neck patients

Physics in Medicine & Biology

journal-article

Classification of various sources of error in range assessment using proton radiography and neural networks in head and neck cancer patients

Physics in Medicine & Biology

journal-article

Evaluation of continuous beam rescanning versus pulsed beam in pencil beam scanned proton therapy for lung tumours

Physics in Medicine & Biology

journal-article

Deep learning-enabled MRI-only photon and proton therapy treatment planning for paediatric abdominal tumours

Radiotherapy and Oncology

journal-article

MR-guided proton therapy: a review and a preview

Radiation Oncology

journal-article

Technical Note: 4D cone‐beam CT reconstruction from sparse‐view CBCT data for daily motion assessment in pencil beam scanned proton therapy (PBS‐PT)

Medical Physics

journal-article

Weekly robustness evaluation of intensity-modulated proton therapy for oesophageal cancer

Radiotherapy and Oncology

journal-article

Evaluation of interplay and organ motion effects by means of 4D dose reconstruction and accumulation

Radiotherapy and Oncology

journal-article

Feasibility of patient specific quality assurance for proton therapy based on independent dose calculation and predicted outcomes

Radiotherapy and Oncology

journal-article

Investigation of inter‐fraction target motion variations in the context of pencil beam scanned proton therapy in non‐small cell lung cancer patients

Medical Physics

journal-article

Assessment of range uncertainty in lung-like tissue using a porcine lung phantom and proton radiography

Physics in Medicine & Biology

journal-article

Time-resolved dosimetry for validation of 4D dose calculation in PBS proton therapy

Physics in Medicine & Biology

journal-article

Deformable image registration uncertainty for inter-fractional dose accumulation of lung cancer proton therapy

Radiotherapy and Oncology

journal-article

Comparison of CBCT based synthetic CT methods suitable for proton dose calculations in adaptive proton therapy

Physics in Medicine & Biology

journal-article

Platform for automatic patient quality assurance via Monte Carlo simulations in proton therapy

Physica Medica

journal-article

Organ sparing potential and inter-fraction robustness of adaptive intensity modulated proton therapy for lung cancer

Acta Oncologica

journal-article

Evaluating the benefit of PBS vs. VMAT dose distributions in terms of dosimetric sparing and robustness against inter-fraction anatomical changes for pediatric abdominal tumors

Radiotherapy and Oncology

journal-article

Real-time intrafraction motion monitoring in external beam radiotherapy

Physics in Medicine & Biology

journal-article

In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field

Radiotherapy and Oncology

journal-article

Comprehensive 4D robustness evaluation for pencil beam scanned proton plans

Radiotherapy and Oncology

journal-article

Log file-based dose reconstruction and accumulation for 4D adaptive pencil beam scanned proton therapy in a clinical treatment planning system: Implementation and proof-of-concept

Medical Physics

journal-article

Feasibility of MRI-only photon and proton dose calculations for pediatric patients with abdominal tumors

Physics in Medicine & Biology

journal-article

Adaptive radiotherapy

edizinische Physik: Grundlagen – Bildgebung – Therapie – Technik

book-chapter

MR-only guided proton therapy : advances, future perspectives and challenges

MRI in Radiation Therapy

journal-article

Feasibility of proton pencil beam scanning treatment of free-breathing lung cancer patients

Acta Oncologica

journal-article

Precision and Uncertainties for Moving Targets

Proton Therapy Physics

book-chapter

Reproducibility of the lung anatomy under active breathing coordinator control: Dosimetric consequences for scanned proton treatments

Medical Physics

journal-article

Motion management in particle therapy

Medical Physics

journal-article

Clinical implementations of 4D pencil beam scanned particle therapy: Report on the 4D treatment planning workshop 2016 and 2017

Physica Medica

journal-article

Assessment of dosimetric errors induced by deformable image registration methods in 4D pencil beam scanned proton treatment planning for liver tumours

Radiotherapy and Oncology

journal-article

An automated, quantitative, and case-specific evaluation of deformable image registration in computed tomography images

Physics in Medicine & Biology

journal-article

Consensus Guidelines for Implementing Pencil-Beam Scanning Proton Therapy for Thoracic Malignancies on Behalf of the PTCOG Thoracic and Lymphoma Subcommittee

International Journal of Radiation Oncology*Biology*Physics

journal-article

Iterative framework for the joint segmentation and CT synthesis of MR images: application to MRI-only radiotherapy treatment planning

Physics in Medicine and Biology

journal-article

An anthropomorphic breathing phantom of the thorax for testing new motion mitigation techniques for pencil beam scanning proton therapy

Physics in Medicine and Biology

journal-article

Evaluation of a multi-atlas CT synthesis approach for MRI-only radiotherapy treatment planning

Physica Medica

journal-article

Required transition from research to clinical application: Report on the 4D treatment planning workshops 2014 and 2015

Physica Medica

journal-article

Robustness of the Voluntary Breath-Hold Approach for the Treatment of Peripheral Lung Tumors Using Hypofractionated Pencil Beam Scanning Proton Therapy

International Journal of Radiation Oncology*Biology*Physics

journal-article

Deep Inspiration Breath Hold—Based Radiation Therapy: A Clinical Review

International Journal of Radiation Oncology*Biology*Physics

journal-article

Improving 4D plan quality for PBS-based liver tumour treatments by combining online image guided beam gating with rescanning

Physics in Medicine and Biology

journal-article

Motion Managment

Principles and Practice of Proton Beam Therapy

book-chapter

Online image guided tumour tracking with scanned proton beams: a comprehensive simulation study

Physics in Medicine and Biology

journal-article

Advances in 4D Treatment Planning for Scanned Particle Beam Therapy — Report of Dedicated Workshops

Technology in Cancer Research & Treatment

journal-article

Quantifying the impact of respiratory-gated 4D CT acquisition on thoracic image quality: A digital phantom study

Medical Physics

journal-article

Challenges of radiotherapy: Report on the 4D treatment planning workshop 2013

Physica Medica

journal-article

In the context of radiosurgery – Pros and cons of rescanning as a solution for treating moving targets with scanned particle beams

Physica Medica

journal-article

In vivo proton range verification: a review

Physics in Medicine and Biology

journal-article

Deformable motion reconstruction for scanned proton beam therapy using on-line x-ray imaging

Physics in Medicine and Biology

journal-article

Comparative study of layered and volumetric rescanning for different scanning speeds of proton beam in liver patients

Physics in Medicine and Biology

journal-article

Adequate margin definition for scanned particle therapy in the incidence of intrafractional motion

Physics in Medicine and Biology

journal-article

Current status and future prospects of multi-dimensional image-guided particle therapy

Radiological Physics and Technology

journal-article

Mapping motion from 4D-MRI to 3D-CT for use in 4D dose calculations: A technical feasibility study

Medical Physics

journal-article

Respiratory liver motion estimation and its effect on scanned proton beam therapy

Physics in Medicine and Biology

journal-article

Scanned proton radiotherapy for mobile targets—the effectiveness of re-scanning in the context of different treatment planning approaches and for different motion characteristics

Physics in Medicine and Biology

journal-article

Extension and validation of an analytical model forin vivoPET verification of proton therapy—a phantom and clinical study

Physics in Medicine and Biology

journal-article

Accuracy of Proton Beam Range Verification Using Post-Treatment Positron Emission Tomography/Computed Tomography as Function of Treatment Site

International Journal of Radiation Oncology*Biology*Physics

journal-article

Special report: Workshop on 4D-treatment planning in actively scanned particle therapy-Recommendations, technical challenges, and future research directions

Medical Physics

journal-article

Systematic analysis of biological and physical limitations of proton beam range verification with offline PET/CT scans

Physics in Medicine and Biology

journal-article

Quantitative assessment of the physical potential of proton beam range verification with PET/CT

Physics in Medicine and Biology

journal-article

PET imaging for treatment verification of ion therapy: Implementation and experience at GSI Darmstadt and MGH Boston

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

journal-article

Patient Study of In Vivo Verification of Beam Delivery and Range, Using Positron Emission Tomography and Computed Tomography Imaging After Proton Therapy

International Journal of Radiation Oncology*Biology*Physics

journal-article

Optimization of extracranial stereotactic radiation therapy of small lung lesions using accurate dose calculation algorithms

Radiation Oncology

journal-article